Monolaurin (90 caps., 300 mg ea.)
Broad spectrum antiviral, antimicrobial agent.
Antiviral Effects of Monolaurin
Monolaurin is an exciting product because its antiviral properties enable selective use of an agent which is non-toxic to humans. Monolaurin works directly on the envelope coat of the virus. By disrupting the conformation of this lipid bilayer, Monolaurin prevents attachment (absorption) to susceptible host cells. As a non-ionic surfactant, it possesses a low potential for gastrointestinal irritability.
Clinical studies have shown that Monolaurin is effective against Herpes I & II, Epstein-Barr virus, Influenza and cytomegalovirus (CMV), all of which share lipid envelope characteristics. Included in this group is the HTLV virus which is tropic towards T-cells.
Chemistry of Monolaurin
An alternative solution to fighting viruses is a new class of safe chemicals, which have been used since antiquity. These chemicals are fatty acids and their corresponding glycerol esters. While fatty acids have been used as genmicides for centuries, glycerol esters of these fatty acids are a recent addition. Because of their lack of toxicity and known biochemical pathway, esters of glycerol have been shown to be more active than their corresponding fatty acids.
The free acid and monoglyceride fraction of cream in milk has antiviral properties, which has led microbiologists to explore the activities of these safe substances.
Lipid pharmacologists have known for over 35 years that specific fatty acids in low concentrations possessed activity against influenza virions. One of these esters, Lauricidin (Monolaurin), has recently been selected for extensive study at medical research centers because of its high antimicrobial activity.
In the human body, the end products of fat digestion are fatty acids, glycerol and glycerides. This means that not only does the body have the machiney to metabolize these substances, but also their pathways are well known. Both the parent substance (lipid) and its metabolic breakdown products are non-toxic.
It is unusual in pharmacology to find chemicals which are toxic to lower forms of life (bacteria, fungi, viruses, etc.) but nontoxic to man or animals. It is this unique property of antimicrobial action and lack of mammalian toxicity which makes fatty acids unique pharmacological agents.
The monoglyceride Lauricidin (Monolaurin) is the most active ester studied at medical research centers.
Monolaurin is present in many plants and has been shown to possess widespectrum activity against fungi and viruses. Monolaurin has been reported to have activity against Semliki forest virus, 14 RNA and DNA-enveloped viruses, lipid-containing bacterial viruses, and the mammalian herpes simplex virus.
What is the Function and Action of Monolaurin?
Not only does Monolaurin exert antiviral activity by direct antiviral activity, but it also enhances both nonspecific as well as specific host defense against viral invasion.
While Monolaurin alone has no effect on lymphocyte or macrophage functions, it potentiates immunological events initiated by other triggering agent such as mitogens, antigens, phagocytic stimuli or lymphokines.
Although it is a broad-spectrum antiviral agent Monolaurin has no effect on disease caused by polio, coxsackie, rotaviruses. Western equine, Venezuela equine,and Japanese B encephalitis viruses. Although it is effective against a number of DNA and RNA viruses it is generally not active against those viruses with genomes acting directly as mRNA,such as poliovirus.Monolaurin does not induce interferon production. It is virustatic and does not induce resistance to the drug.
Monolaurin given orally is generally well tolerated. Gastrointestinal symptoms are rare. No significant abnormalities have been noted in liver enzymes, total leukocyte count, red cell count, hematocrit, hemoglobin, or platelet levels.
In studies performed at the Respiratory Viroiogy Branch, Center for Disease Control Atlanta Georgia, Monolaurin was tested for vinrcidal activity against 14 human RNA and DNA enveloped viruses in cell culture. Monolaurin removed 99.9% or all measurable infectivity of the 14 viruses by disintegrating the virus envelope. The viruses used were prototype or recognized representative strains of enveloped human viruses obtained from the reference virus collection at the CDC.